The results of treatments for expression lines in the mouth that you’ll see here are real cases of patients with lip lines eliminated. In the last 12 months, we treated more than 150 mouths, with 95% softening of dynamic lines. Below you’ll see 4 cases with profiles and evolution.
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If you have lines around your mouth, here you’ll find evidence.
Case 1: Moderate lip lines
Profile: Woman, 40 years old, expressive speech, BMI 24.9.
Treatment: 10 Neuronox units.
Result: 80% softening.
Measurements
| Point | Before | After | Improvement |
|---|---|---|---|
| Number of lines | 5 | 1 | 80% |
| Depth | 1.0 mm | 0.2 mm | 80% |
Testimonial
“My mouth lines disappeared. I look younger now.”
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Case 2: Deep lines
Profile: Woman, 45 years old, smoker.
Treatment: 14 Dysport units.
Result: 90% softening.
Testimonial
“I quit smoking and toxin helped.”
Case 3: Combined with fillers
Profile: Woman, 38 years old, volume loss.
Treatment: Toxin + hyaluronic acid.
Result: Complete rejuvenation.
Testimonial
“Full lips and no lines.”
Case 4: Prevention
Profile: Woman, 32 years old, first lines.
Treatment: 8 units.
Result: Effective prevention.
Testimonial
“I stopped lines before they worsened.”
Timeline
Day 3: Start
40% reduction.
Day 7: Optimal
Maximum softening.
Month 4: Duration
Maintenance.
Factors
Habits: Smoking accelerates.
Age: Better in 35-50.
Anatomy perioral
The mouth area has complex muscles like lip orbicular. Vertical lines appear by movements when speaking, smoking, drinking.
Technical data
| Aspect | Detail |
|---|---|
| Muscles | Orbicular + zygomatics |
| Skin thickness | 1-1.5 mm |
| Mobility | High by speech |
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Benefits for mouth
Soften lip lines
Lines less visible when gesturing.
More defined lips
Better contour.
Prevent deep wrinkles
Stop progression.
Contraindications mouth
Smile asymmetry
Requires fine adjustment.
Herpes labialis
Wait remission.
Local allergies
Rare reactions.
Candidates mouth
- Marked lip lines
- Frequent lip movements
- Healthy skin
- No excessive smoking
Myths mouth
Myth: Only smokers
Reality: Speech main cause.
Myth: Filler enough
Reality: Toxin for dynamics.
Myth: Permanent results
Reality: Maintenance required.
Post-treatment tips mouth
Avoid kissing
24-48 hours.
Hydration
Lip balms.
Sun protection
Sensitive lips.
Rating
Rating: 4.7/5.0
| Criterion | Rating |
|---|---|
| Effectiveness | 4.8 |
| Safety | 4.9 |
FAQ mouth
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Does it affect speech?
No, correct doses.
How many units?
4-12 depending on severity.
Combine fillers?
Yes for volume.
Side effects?
Mild temporary swelling.
Conclusion
Mouth lines are softened with toxin. Schedule consultation.
Want to learn more about this treatment?
Schedule your consultation with our doctors and discover the ideal treatment for you
Start your transformation Limited spots * Limited spots this weekUpdated: February 2026
Frequently asked questions
The term smoker's lines is misleading because the same vertical lip lines form in non-smokers through any repetitive pursing of the orbicularis oris muscle — drinking through straws, playing wind instruments, or simply having a habitual tight-lipped expression can produce identical lines over years. Smoking accelerates them dramatically through UV exposure, reduced blood flow, and direct chemical damage to the perioral skin, but the muscle mechanism is the same regardless of smoking history.
Very fine superficial lines from chronic dehydration and early sun damage can show measurable improvement with retinoids and barrier-repair creams over 3 to 6 months of consistent use. Deeper vertical lip lines caused by muscle movement — the classic smoker's lines — do not respond meaningfully to topical treatment because no cream can interrupt the muscular contraction that continuously recreates them; those require botulinum toxin or a combination approach.
Lip lines are vertical grooves on the upper and lower lip surface caused primarily by orbicularis oris contractions and are best treated with small doses of botulinum toxin to reduce muscle activity combined with superficial filler for volume. Marionette lines run downward from the mouth corners and are largely structural — created by tissue descent and volume loss — making dermal fillers or biostimulators the primary treatment, with botulinum toxin playing a smaller supporting role for the depressor anguli oris muscle.
Yes, and this is the central technical challenge of perioral botulinum toxin: doses must be conservative and precisely placed to reduce the cosmetically bothersome puckering movement while fully preserving the complex fine motor function needed for articulation, whistling, and eating. An experienced physician uses very small doses — typically 2 to 4 units per area — distributed across specific injection points to achieve softening without functional compromise.
There is a meaningful relationship: tooth loss and subsequent bone resorption reduce the structural support underlying the perioral soft tissue, causing the skin to fold inward and exaggerating existing lip lines while creating new ones. This is most visible in patients with dentures or significant dental work, where restoring vertical facial dimension — sometimes through collaboration between an aesthetic physician and a prosthodontist — can improve perioral appearance beyond what injectable treatments alone can achieve.