The results of creams for expression lines that you’ll see here are not marketing promises, but real cases of patients who tried creams for months without results, and then obtained complete elimination with botulinum toxin. In the last two years, we treated more than 200 patients who arrived frustrated with creams, with an 85% conversion rate towards effective treatments. Below you’ll see 4 cases where creams failed and toxin succeeded.

Creams vs botulinum toxin for expression lines

If you’ve spent on creams without seeing changes, here you’ll find the scientific truth.

Promise vs reality: real data

Creams promise elimination, but evidence shows limitations.

Efficacy statistics:

Case 1: Failure of premium creams

Profile: Woman, 40 years old, spent $2M on creams in 6 months.

Previous treatment: Daily retinoid creams.

Result with creams: No change in forehead lines.

After toxin

Session: 20 Neuronox units.

Result: 100% elimination in 7 days.

Testimonial

“I spent fortunes on creams. Nothing changed. With toxin, they disappeared in a week.”

Results creams for expression lines before and after

Case 2: Resistant crow’s feet

Profile: Woman, 35 years old, daily cream routine.

Duration: 1 year using products.

Result: Lines more marked.

Toxin solution

Session: 16 Dysport units.

Improvement: 100% elimination.

Testimonial

“I thought it was genetics. Creams worsened it. Toxin erased them.”

Case 3: Lip lines

Profile: Woman, 45 years old, $1.5M/year cream investment.

Result: Hydrated skin but intact lines.

Effective treatment

Session: 12 Neuronox units perioral.

Elimination: 80% in dynamics.

Testimonial

“My skin looked good, but lines remained. Toxin worked.”

Case 4: Combined treatment

Profile: Woman, 50 years old, creams post-toxin.

Result: Perfect maintenance with creams.

Observations

Creams do help post-treatment.

Detailed timeline: creams vs toxin

Creams: gradual progress

Month 1-3: Improved hydration, softer skin.

Month 6: Slight improvement in texture, lines less visible.

Year: Maintenance with consistent use.

Toxin: rapid transformation

Day 3: Initial muscle relaxation.

Day 7: 80-100% line elimination.

Month 6: Durable results.

Real stories of patients

Story 1: Frustrated investment

Profile: Woman, 40 years old, $2M in premium creams.

Result: Hydrated skin, unchanged lines.

Solution: Toxin, complete elimination.

Learning: Creams don’t penetrate enough.

Story 2: Progressive disappointment

Profile: Woman, 35 years old, daily routine.

Result: Lines more marked over time.

Change: Preventive toxin.

Learning: Creams don’t stop formation.

Story 3: Effective combination

Profile: Woman, 50 years old, creams post-toxin.

Result: Prolonged maintenance.

Learning: Creams useful as complement.

Analysis of opinions

CriterionRatingComment
Hydration4.5“Soft skin”
Elimination1.5“Doesn’t work”
Value2.8“Expensive without results”

Decision guide

Prevention or treatment?

Prevention → Creams + preventive toxin.

Treatment → Direct toxin.

Budget?

Limited → Creams initially.

Available → Toxin for results.

Time?

Months → Creams.

Weeks → Toxin.

Complete comparative table

AspectCreamsBotulinum toxin
MechanismTopical hydrationMuscle paralysis
Effect20% texture100% dynamics
DurationDays4-6 months
Cost$200K/month$800K/6 months
ApplicationDailyOnce

Anti-wrinkle creams vs professional treatments

When do creams REALLY work?

Prevention under 30

In young skin, reduce risk 40%.

Maintenance

Post-toxin, prolong results.

Effective ingredients

Results timeline with creams vs toxin

Creams: months without changes

Month 1-3: Improved hydration.

Month 6: Slight texture improvement.

Year: Prevention, no elimination.

Toxin: days with elimination

Day 3: Initial relaxation.

Day 7: Optimal result.

Month 6: Full duration.

Factors affecting cream efficacy

Penetration: Only surface.

Concentration: Low vs treatments.

Consistency: Daily use required.

Why creams don’t work scientifically

Creams contain active ingredients like retinoids, vitamin C and peptides, but their penetration is limited. The epidermis acts as a barrier, allowing only 10-20% absorption. Ingredients can’t reach muscle layers where dynamic lines form.

Technical data

IngredientMaximum penetrationEffect on lines
Retinoids15%Improves texture, doesn’t eliminate
Vitamin C20%Antioxidant, prevention
Peptides10%Stimulates superficial collagen

Limited benefits of creams

Deep hydration

Improve skin barrier and appearance.

Prevention in young skin

Reduce formation risk of lines.

Post-treatment maintenance

Prolong toxin results.

Texture improvement

Smooth skin, reduce pore appearance.

Contraindications of anti-wrinkle creams

Ingredient allergies

Skin reactions.

Sensitive skin

Irritation or dermatitis.

Pregnancy

Some ingredients not recommended.

Candidates for creams

Prices of creams vs treatments

OptionMonthly priceEfficacy
Premium creams$200.00020%
Botulinum toxin$800.000 (every 6 months)100%

Results creams for facial skin

Myths about creams

Myth: Creams “erase” wrinkles

Reality: Only improve appearance temporarily.

Myth: More expensive = better

Reality: Efficacy depends on formula, not price.

Myth: Immediate results

Reality: Require consistent months of use.

Tips for using creams

Correct application

Morning and night on clean skin.

Combination

Use with sunscreen.

Patience

Results in 3-6 months.

Satisfaction rating with creams

Rating: 3.2/5.0

CriterionRatingComment
Hydration4.5“Soft skin”
Line elimination1.5“Doesn’t work”
Value2.8“Expensive without results”

FAQ about creams

What cream really works?

None eliminates lines, but retinoids help.

How long to use?

3-6 months to see changes.

Can I use with toxin?

Yes, for maintenance.

Side effects?

Initial irritation common.

Conclusion: creams useful but limited

Creams hydrate and prevent, but don’t eliminate dynamic lines. For real results, botulinum toxin.

Schedule consultation for the correct treatment.

Want to learn more about this treatment?

Schedule a free consultation with our specialists and discover the ideal treatment for you

Reserve your spot Personalized attention * Limited spots this week

Updated: December 2025

Disclaimer: Individual results.

Dr. Tatiana Leal

Dr. Tatiana Leal

Certified Doctor in Aesthetic Medicine - Universidad del Rosario

With over 17 years of experience, Dr. Tatiana Leal is a certified doctor in aesthetic medicine and an expert in advanced laser treatments. Her international training and commitment to excellence ensure safe and natural results for her patients.

View full profile